The K(ATP) Channel Activator Diazoxide Ameliorates Aβ and Tau Pathologies and Improves Memory in the 3xTgAD Mouse Model of Alzheimer's Disease

Compromised cellular energy metabolism, cerebral hypoperfusion and neuronal calcium dysregulation are involved in the pathological process of Alzheimer's disease (AD). ATP-sensitive potassium (K(ATP)) channels in plasma membrane and inner mitochondrial membrane play important roles in modulatin...

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Bibliografiske detaljer
Main Authors: Liu, Dong, Pitta, Michael, Lee, Jong-Hwan, Ray, Balmiki, Lahiri, Debomoy, Furukawa, Katsutoshi, Mughal, Mohamed, Jiang, Haiyang, Villarreal, Julissa, Cutler, Roy G., Greig, Nigel H., Mattson, Mark P.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988870/
https://ncbi.nlm.nih.gov/pubmed/20847430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2010-101017
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