Prophylactic Treatment with Paroxetine Ameliorates Behavioral Deficits and Retards the Development of Amyloid and Tau Pathologies in 3xTgAD Mice

A history of depression is a risk factor for Alzheimer’s disease (AD), suggesting the possibility that antidepressants administered prophylactically might retard the disease process and preserve cognitive function. Here we report that pre-symptomatic treatment with the antidepressant paroxetine atte...

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Main Authors: Nelson, Rhonda L., Guo, Zhihong, Halagappa, Veerendra Madala, Pearson, Michelle, Gray, Audrey J., Matsuoka, Yasuji, Brown, Martin, Clark, Robert F., Mattson, Mark P.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1979096/
https://ncbi.nlm.nih.gov/pubmed/17368447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2007.01.037
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