Systemic treatment with liver X receptor agonists raises apolipoprotein E, cholesterol, and amyloid-β peptides in the cerebral spinal fluid of rats

BACKGROUND: Apolipoprotein E (apoE) is a major cholesterol transport protein found in association with brain amyloid from Alzheimer's disease (AD) patients and the ε4 allele of apoE is a genetic risk factor for AD. Previous studies have shown that apoE forms a stable complex with amyloid β (Aβ)...

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Main Authors: Suon, Sokreine, Zhao, Jie, Villarreal, Stephanie A, Anumula, Nikesh, Liu, Mali, Carangia, Linda M, Renger, John J, Zerbinatti, Celina V
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988784/
https://ncbi.nlm.nih.gov/pubmed/21034469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-5-44
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