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Dominant-negative Dmp53 extends life span through the dTOR pathway in D. melanogaster
Expression of dominant-negative (DN) versions of the Drosophila ortholog of the tumor suppressor p53 extends fly life span in a Calorie Restriction (CR) dependent manner. DN-Dmp53 expression furthermore leads to reduction of Drosophila insulin-like peptide (dILP) 2 mRNA levels and a decrease in insu...
Tallennettuna:
| Päätekijät: | , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
2010
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2988653/ https://ncbi.nlm.nih.gov/pubmed/20117129 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2010.01.007 |
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