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Expression of dominant-negative Dmp53 in the adult fly brain inhibits insulin signaling
In Drosophila melanogaster, p53 (Dmp53) is an important mediator of longevity. Expression of dominant-negative (DN) forms of Dmp53 in adult neurons, but not in muscle or fat body cells, extends lifespan. The lifespan of calorie-restricted flies is not further extended by simultaneously expressing DN...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1948898/ https://ncbi.nlm.nih.gov/pubmed/17686972 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0706121104 |
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