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Channel-Opening Kinetic Mechanism for Human Wild-Type GluK2 and the M867I Mutant Kainate Receptor
GluK2 is a kainate receptor subunit that is alternatively spliced at the C-terminus. Previous studies implicated GluK2 in autism. In particular, the methionine-to-isoleucine replacement at amino acid residue 867 (M867I) that can only occur in the longest isoform of the human GluK2 (hGluK2), as the d...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2010
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2988652/ https://ncbi.nlm.nih.gov/pubmed/20863077 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100819v |
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