Apolipoprotein E4 Causes Age- and Tau-Dependent Impairment of GABAergic Interneurons, Leading to Learning and Memory Deficits in Mice

Apolipoprotein E4 (apoE4) is the major genetic risk factor for Alzheimer's disease. However, the underlying mechanisms are unclear. We found that female apoE4 knock-in (KI) mice had an age-dependent decrease in hilar GABAergic interneurons that correlated with the extent of learning and memory...

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Detalhes bibliográficos
Main Authors: Andrews-Zwilling, Yaisa, Bien-Ly, Nga, Xu, Qin, Li, Gang, Bernardo, Aubrey, Yoon, Seo Yeon, Zwilling, Daniel, Yan, Tonya Xue, Chen, Ligong, Huang, Yadong
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2010
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988475/
https://ncbi.nlm.nih.gov/pubmed/20943911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4040-10.2010
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