Apolipoprotein E4 Causes Age- and Tau-Dependent Impairment of GABAergic Interneurons, Leading to Learning and Memory Deficits in Mice

Apolipoprotein E4 (apoE4) is the major genetic risk factor for Alzheimer's disease. However, the underlying mechanisms are unclear. We found that female apoE4 knock-in (KI) mice had an age-dependent decrease in hilar GABAergic interneurons that correlated with the extent of learning and memory...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Andrews-Zwilling, Yaisa, Bien-Ly, Nga, Xu, Qin, Li, Gang, Bernardo, Aubrey, Yoon, Seo Yeon, Zwilling, Daniel, Yan, Tonya Xue, Chen, Ligong, Huang, Yadong
Médium: Artigo
Jazyk:Inglês
Vydáno: Society for Neuroscience 2010
Témata:
Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988475/
https://ncbi.nlm.nih.gov/pubmed/20943911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.4040-10.2010
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky