Identification of the Drosophila Ortholog of HSPB8: IMPLICATION OF HSPB8 LOSS OF FUNCTION IN PROTEIN FOLDING DISEASES

Protein aggregation is a hallmark of many neuronal disorders, including the polyglutamine disorder spinocerebellar ataxia 3 and peripheral neuropathies associated with the K141E and K141N mutations in the small heat shock protein HSPB8. In cells, HSPB8 cooperates with BAG3 to stimulate autophagy in...

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Autores principales: Carra, Serena, Boncoraglio, Alessandra, Kanon, Bart, Brunsting, Jeanette F., Minoia, Melania, Rana, Anil, Vos, Michel J., Seidel, Kay, Sibon, Ody C. M., Kampinga, Harm H.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Protein Synthesis and Degradation
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988385/
https://ncbi.nlm.nih.gov/pubmed/20858900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.127498
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