Optimization of the Degenerated Interfacial ATP Binding Site Improves the Function of Disease-related Mutant Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Channels

The cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel, an ATP binding cassette (ABC) protein whose defects cause the deadly genetic disease cystic fibrosis (CF), encompasses two nucleotide binding domains (NBD1 and NBD2). Recent studies indicate that in the presence of ATP,...

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Detalhes bibliográficos
Main Authors: Tsai, Ming-Feng, Jih, Kang-Yang, Shimizu, Hiroyasu, Li, Min, Hwang, Tzyh-Chang
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988371/
https://ncbi.nlm.nih.gov/pubmed/20861014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.172817
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