Dual Modes of Interaction between XRCC4 and Polynucleotide Kinase/Phosphatase: IMPLICATIONS FOR NONHOMOLOGOUS END JOINING

XRCC4 plays a crucial role in the nonhomologous end joining (NHEJ) pathway of DNA double-strand break repair acting as a scaffold protein that recruits other NHEJ proteins to double-strand breaks. Phosphorylation of XRCC4 by protein kinase CK2 promotes a high affinity interaction with the forkhead-a...

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Detalhes bibliográficos
Main Authors: Mani, Rajam S., Yu, Yaping, Fang, Shujuan, Lu, Meiling, Fanta, Mesfin, Zolner, Angela E., Tahbaz, Nasser, Ramsden, Dale A., Litchfield, David W., Lees-Miller, Susan P., Weinfeld, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988367/
https://ncbi.nlm.nih.gov/pubmed/20852255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.058719
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