HIV protease inhibitors elicit volume-sensitive Cl(−) current in cardiac myocytes via mitochondrial ROS

HIV protease inhibitors (HIV PI) reduce morbidity and mortality of HIV infection but cause multiple untoward effects. Because certain HIV PI evoke production of reactive oxygen species (ROS) and volume-sensitive Cl(−) current (I(Cl,swell)) is activated by ROS, we tested whether HIV PI stimulate I(Cl...

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Bibliographic Details
Main Authors: Deng, Wu, Baki, Lia, Yin, Jun, Zhou, Huiping, Baumgarten, Clive M.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988286/
https://ncbi.nlm.nih.gov/pubmed/20736017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2010.08.013
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