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HIV protease inhibitors elicit volume-sensitive Cl(−) current in cardiac myocytes via mitochondrial ROS

HIV protease inhibitors (HIV PI) reduce morbidity and mortality of HIV infection but cause multiple untoward effects. Because certain HIV PI evoke production of reactive oxygen species (ROS) and volume-sensitive Cl(−) current (I(Cl,swell)) is activated by ROS, we tested whether HIV PI stimulate I(Cl...

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Détails bibliographiques
Auteurs principaux: Deng, Wu, Baki, Lia, Yin, Jun, Zhou, Huiping, Baumgarten, Clive M.
Format: Artigo
Langue:Inglês
Publié: 2010
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988286/
https://ncbi.nlm.nih.gov/pubmed/20736017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2010.08.013
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