Chronic OVA allergen challenged Siglec-F deficient mice have increased mucus, remodeling, and epithelial Siglec-F ligands which are up-regulated by IL-4 and IL-13

BACKGROUND: In this study we examined the role of Siglec-F, a receptor highly expressed on eosinophils, in contributing to mucus expression, airway remodeling, and Siglec-F ligand expression utilizing Siglec-F deficient mice exposed to chronic allergen challenge. METHODS: Wild type (WT) and Siglec-F...

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Bibliografiske detaljer
Main Authors: Cho, Jae Youn, Song, Dae Jae, Pham, Alexa, Rosenthal, Peter, Miller, Marina, Dayan, Shanna, Doherty, Taylor A, Varki, Ajit, Broide, David H
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2988013/
https://ncbi.nlm.nih.gov/pubmed/21040544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1465-9921-11-154
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