Anti-Siglec-F Antibody Reduces Allergen-Induced Eosinophilic Inflammation and Airway Remodeling

Siglec-F is a sialic acid-binding Ig superfamily receptor that is highly expressed on eosinophils. We have investigated whether administration of an anti-Siglec-F Ab to OVA-challenged wild-type mice would reduce levels of eosinophilic inflammation and levels of airway remodeling. Mice sensitized to...

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Bibliographic Details
Main Authors: Song, Dae Jin, Cho, Jae Youn, Lee, Sang Yeub, Miller, Marina, Rosenthal, Peter, Soroosh, Pejman, Croft, Michael, Zhang, Mai, Varki, Ajit, Broide, David H.
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2788790/
https://ncbi.nlm.nih.gov/pubmed/19783675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0801421
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