Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model

BACKGROUND: α-Synuclein aggregates in Lewy bodies and plays a central role in the pathogenesis of a group of neurodegenerative disorders, known as "Synucleinopathies", including Parkinson's disease. Parkin mutations result in loss of parkin E3-ubiquitin ligase activity and cause autos...

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Bibliografiske detaljer
Main Authors: Khandelwal, Preeti J, Dumanis, Sonya B, Feng, Li Rebekah, Maguire-Zeiss, Kathleen, Rebeck, GW, Lashuel, Hilal A, Moussa, Charbel EH
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2010
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2987994/
https://ncbi.nlm.nih.gov/pubmed/21050448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-5-47
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