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Parkinson-related parkin reduces α-Synuclein phosphorylation in a gene transfer model
BACKGROUND: α-Synuclein aggregates in Lewy bodies and plays a central role in the pathogenesis of a group of neurodegenerative disorders, known as "Synucleinopathies", including Parkinson's disease. Parkin mutations result in loss of parkin E3-ubiquitin ligase activity and cause autos...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
BioMed Central
2010
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2987994/ https://ncbi.nlm.nih.gov/pubmed/21050448 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-5-47 |
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