Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model

BACKGROUND: Although increasing evidence has indicated that brain insulin dysfunction is a risk factor for Alzheimer disease (AD), the underlying mechanisms by which insulin deficiency may impact the development of AD are still obscure. Using a streptozotocin (STZ)-induced insulin deficient diabetic...

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Hlavní autoři: Wang, Xu, Zheng, Wei, Xie, Jing-Wei, Wang, Tao, Wang, Si-Ling, Teng, Wei-Ping, Wang, Zhan-You
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2010
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2987993/
https://ncbi.nlm.nih.gov/pubmed/21044348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1750-1326-5-46
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