Crystal Structure and Size-Dependent Neutralization Properties of HK20, a Human Monoclonal Antibody Binding to the Highly Conserved Heptad Repeat 1 of gp41

The human monoclonal antibody (mAb) HK20 neutralizes a broad spectrum of primary HIV-1 isolates by targeting the highly conserved heptad repeat 1 (HR1) of gp41, which is transiently exposed during HIV-1 entry. Here we present the crystal structure of the HK20 Fab in complex with a gp41 mimetic 5-Hel...

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Auteurs principaux: Sabin, Charles, Corti, Davide, Buzon, Victor, Seaman, Mike S., Lutje Hulsik, David, Hinz, Andreas, Vanzetta, Fabrizia, Agatic, Gloria, Silacci, Chiara, Mainetti, Lara, Scarlatti, Gabriella, Sallusto, Federica, Weiss, Robin, Lanzavecchia, Antonio, Weissenhorn, Winfried
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2010
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2987821/
https://ncbi.nlm.nih.gov/pubmed/21124990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1001195
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