Deletion of the RAG2 C terminus leads to impaired lymphoid development in mice

The recombination-activating gene (RAG)1 and RAG2 proteins comprise the lymphocyte-specific components of the V(D)J recombinase and are required for the assembly of antigen-receptor variable-region genes. A mutant truncated RAG2 protein (“core” RAG2) lacking the C-terminal 144 amino acids, together...

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Main Authors: Akamatsu, Yoshiko, Monroe, Robert, Dudley, Darryll D., Elkin, Sheryl K., Gärtner, Frank, Talukder, Sadiqur R., Takahama, Yousuke, Alt, Frederick W., Bassing, Craig H., Oettinger, Marjorie A.
格式: Artigo
語言:Inglês
出版: The National Academy of Sciences 2003
主題:
Biological Sciences
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC298752/
https://ncbi.nlm.nih.gov/pubmed/12531919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0237043100
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