Without peripheral interference, thymic deletion is mediated in a cohort of double-positive cells without classical activation

Peripheral activation can cause bystander thymocyte death by eliciting a “cytokine storm.” This event complicates in vivo studies using exogenous ligand-induced models of negative selection. A stable transgenic model that selectively eliminates peripheral CD4 cells has allowed us to analyze negative...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Zhan, Yifan, Purton, Jared F., Godfrey, Dale I., Cole, Timothy J., Heath, William R., Lew, Andrew M.
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 2003
Sujets:	Biological Sciences
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298750/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12538873/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0237316100
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