Without peripheral interference, thymic deletion is mediated in a cohort of double-positive cells without classical activation
Peripheral activation can cause bystander thymocyte death by eliciting a “cytokine storm.” This event complicates in vivo studies using exogenous ligand-induced models of negative selection. A stable transgenic model that selectively eliminates peripheral CD4 cells has allowed us to analyze negative...
Kaydedildi:
| Yayımlandı: | Proc Natl Acad Sci U S A |
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| Asıl Yazarlar: | , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
National Academy of Sciences
2003
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298750/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12538873/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0237316100 |
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