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Without peripheral interference, thymic deletion is mediated in a cohort of double-positive cells without classical activation
Peripheral activation can cause bystander thymocyte death by eliciting a “cytokine storm.” This event complicates in vivo studies using exogenous ligand-induced models of negative selection. A stable transgenic model that selectively eliminates peripheral CD4 cells has allowed us to analyze negative...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC298750/ https://ncbi.nlm.nih.gov/pubmed/12538873 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0237316100 |
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