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Optimized expression and specific activity of IL-12 by directed molecular evolution
DNA delivery of IL-12 has shown promise in reducing the toxic side effects associated with administration of recombinant human (h)IL-12 protein while maintaining the ability to inhibit tumor growth and abolish tumor metastases in animal models. We have developed a more potent version of IL-12 by usi...
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| 主要な著者: | , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The National Academy of Sciences
2003
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC298744/ https://ncbi.nlm.nih.gov/pubmed/12529500 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0237327100 |
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