Optimized expression and specific activity of IL-12 by directed molecular evolution

DNA delivery of IL-12 has shown promise in reducing the toxic side effects associated with administration of recombinant human (h)IL-12 protein while maintaining the ability to inhibit tumor growth and abolish tumor metastases in animal models. We have developed a more potent version of IL-12 by usi...

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Main Authors: Leong, Steven R., Chang, Jean C. C., Ong, Randal, Dawes, Glenn, Stemmer, Willem P. C., Punnonen, Juha
Formáid: Artigo
Teanga:Inglês
Foilsithe: The National Academy of Sciences 2003
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC298744/
https://ncbi.nlm.nih.gov/pubmed/12529500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0237327100
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