Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma

Sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) promotes the apoptosis of eosinophils and inhibits FcɛRI-dependent mediator release from mast cells. We investigated the genetic association between sequence variants in Siglec-8 and diagnosis of asthma, total levels of serum IgE (tIgE), an...

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Autors principals: Gao, Pei-Song, Shimizu, Kenichi, Grant, Audrey V, Rafaels, Nicholas, Zhou, Lin-Fu, Hudson, Sherry A, Konno, Satoshi, Zimmermann, Nives, Araujo, Maria I, Ponte, Eduardo V, Cruz, Alvaro A, Nishimura, Masaharu, Su, Song-Nan, Hizawa, Nobuyuki, Beaty, Terry H, Mathias, Rasika A, Rothenberg, Marc E, Barnes, Kathleen C, Bochner, Bruce S
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2987348/
https://ncbi.nlm.nih.gov/pubmed/20087405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ejhg.2009.239
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