Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells

Mouse embryonic stem (ES) cells differentiate into cells of all three primary germ layers including endodermal cells that produce insulin in vitro. We show that constitutive expression of Pax4 (Pax4(+)), and to a lesser extent Pdx1 (Pdx1(+)), affects the differentiation of ES cells and significantly...

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Detaylı Bibliyografya
Asıl Yazarlar: Blyszczuk, Przemyslaw, Czyz, Jaroslaw, Kania, Gabriela, Wagner, Martin, Roll, Ursula, St-Onge, Luc, Wobus, Anna M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences 2003
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC298715/
https://ncbi.nlm.nih.gov/pubmed/12525695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0237371100
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