Expression of Pax4 in embryonic stem cells promotes differentiation of nestin-positive progenitor and insulin-producing cells

Mouse embryonic stem (ES) cells differentiate into cells of all three primary germ layers including endodermal cells that produce insulin in vitro. We show that constitutive expression of Pax4 (Pax4(+)), and to a lesser extent Pdx1 (Pdx1(+)), affects the differentiation of ES cells and significantly...

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Hlavní autoři: Blyszczuk, Przemyslaw, Czyz, Jaroslaw, Kania, Gabriela, Wagner, Martin, Roll, Ursula, St-Onge, Luc, Wobus, Anna M.
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 2003
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC298715/
https://ncbi.nlm.nih.gov/pubmed/12525695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0237371100
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