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Structural evidence for substrate strain in antibody catalysis
The crystal structure of the Michaelis complex between the Fab fragment of ferrochelatase antibody 7G12 and its substrate mesoporphyrin has been solved to 2.6-Å resolution. The antibody-bound mesoporphyrin clearly adopts a nonplanar conformation and reveals that the antibody catalyzes the porphyrin...
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| Main Authors: | , , , , |
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| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
The National Academy of Sciences
2003
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC298691/ https://ncbi.nlm.nih.gov/pubmed/12552112 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0235873100 |
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