Structural evidence for substrate strain in antibody catalysis

The crystal structure of the Michaelis complex between the Fab fragment of ferrochelatase antibody 7G12 and its substrate mesoporphyrin has been solved to 2.6-Å resolution. The antibody-bound mesoporphyrin clearly adopts a nonplanar conformation and reveals that the antibody catalyzes the porphyrin...

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Detaylı Bibliyografya
Asıl Yazarlar: Yin, Jun, Andryski, Scott E., Beuscher, Albert E., Stevens, Raymond C., Schultz, Peter G.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The National Academy of Sciences 2003
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC298691/
https://ncbi.nlm.nih.gov/pubmed/12552112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0235873100
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