Mapping the active-site tyrosine of vaccinia virus DNA topoisomerase I.
Site-directed mutagenesis of the vaccinia virus gene encoding a type I DNA topoisomerase implicates Tyr-274 as the active-site residue that forms a covalent adduct with DNA during cycles of DNA-strand breakage and reunion. Replacement of Tyr-274 by phenylalanine results in loss of the ability of the...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
1989
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298588/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2557629/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.24.9793 |
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