Mapping the active-site tyrosine of vaccinia virus DNA topoisomerase I.

Site-directed mutagenesis of the vaccinia virus gene encoding a type I DNA topoisomerase implicates Tyr-274 as the active-site residue that forms a covalent adduct with DNA during cycles of DNA-strand breakage and reunion. Replacement of Tyr-274 by phenylalanine results in loss of the ability of the...

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Julkaisussa:	Proc Natl Acad Sci U S A
Päätekijät:	Shuman, S, Kane, E M, Morham, S G
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	National Academy of Sciences 1989
Aiheet:	Research Article
Linkit:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298588/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2557629/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.24.9793
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