Inhibition of human immunodeficiency virus 1 protease in vitro: rational design of substrate analogue inhibitors.

Inhibitors of the protease from human immunodeficiency virus 1 (HIV-1) were designed, synthesized, and kinetically characterized. Analogues of a heptapeptide substrate of HIV-1 protease with sequence similar to the p17-p24 cleavage site in the natural substrate, Pr55gag, were synthesized in which th...

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Main Authors: Dreyer, G B, Metcalf, B W, Tomaszek, T A, Carr, T J, Chandler, A C, Hyland, L, Fakhoury, S A, Magaard, V W, Moore, M L, Strickler, J E
格式: Artigo
語言:Inglês
出版: 1989
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC298579/
https://ncbi.nlm.nih.gov/pubmed/2690072
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