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Inhibition of human immunodeficiency virus 1 protease in vitro: rational design of substrate analogue inhibitors.

Inhibitors of the protease from human immunodeficiency virus 1 (HIV-1) were designed, synthesized, and kinetically characterized. Analogues of a heptapeptide substrate of HIV-1 protease with sequence similar to the p17-p24 cleavage site in the natural substrate, Pr55gag, were synthesized in which th...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Dreyer, G B, Metcalf, B W, Tomaszek, T A, Carr, T J, Chandler, A C, Hyland, L, Fakhoury, S A, Magaard, V W, Moore, M L, Strickler, J E
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 1989
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298579/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2690072/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.24.9752
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