Inhibition of human immunodeficiency virus 1 protease in vitro: rational design of substrate analogue inhibitors.

Inhibitors of the protease from human immunodeficiency virus 1 (HIV-1) were designed, synthesized, and kinetically characterized. Analogues of a heptapeptide substrate of HIV-1 protease with sequence similar to the p17-p24 cleavage site in the natural substrate, Pr55gag, were synthesized in which th...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Dreyer, G B, Metcalf, B W, Tomaszek, T A, Carr, T J, Chandler, A C, Hyland, L, Fakhoury, S A, Magaard, V W, Moore, M L, Strickler, J E
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1989
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298579/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2690072/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.24.9752
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