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Prevention of experimental encephalomyelitis with peptides that block interaction of T cells with major histocompatibility complex proteins.

Two synthetic immunodominant and nonencephalitogenic peptides of myelin basic protein, N1-20 and AcN9-20, effectively compete with an encephalitogenic peptide, AcN1-11, in an in vitro T-cell response restricted by class II major histocompatibility complex products (I-Au). These mutant peptide constr...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Sakai, K, Zamvil, S S, Mitchell, D J, Hodgkinson, S, Rothbard, J B, Steinman, L
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1989
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298518/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2480602/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.23.9470
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