The ASK1-Signalosome regulates p38 MAPK activity in response to levels of endogenous oxidative stress in the Klotho mouse models of aging

Reactive oxygen species (ROS) and elevated levels of p38 MAPK activity accelerate physiological aging. This emphasizes the importance of understanding the molecular mechanism(s) that link ROS production to activation of the p38 mediated promotion of aging, longevity, and resistance to oxidative stre...

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Hauptverfasser: Hsieh, C-C, Kuro-o, Makoto, Rosenblatt, Kevin P., Brobey, Reynolds, Papaconstantinou, John
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2010
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2984608/
https://ncbi.nlm.nih.gov/pubmed/20844314
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