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Thioredoxin-ASK1 complex levels regulate ROS-mediated p38 MAPK pathway activity in livers of aged and long-lived Snell dwarf mice

We have proposed that the age-associated increase of reactive oxygen species (ROS) by electron transport chain (ETC) dysfunction may cause the elevated basal level of p38 MAPK stress response pathway activity. However, the mechanism by which ROS activates this pathway is not clear. Here we propose t...

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Hlavní autoři: Hsieh, Ching-Chyuan, Papaconstantinou, John
Médium: Artigo
Jazyk:Inglês
Vydáno: 2006
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1479092/
https://ncbi.nlm.nih.gov/pubmed/16449798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.05-4376com
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