Klotho interferes with a novel FGF-signalling pathway and insulin/Igf-like signalling to improve longevity and stress resistance in Caenorhabditis elegans

Klotho exerts anti-aging properties in mammals in two different ways. While membrane-bound Klotho, which is primarily expressed in the kidney, acts as an obligate co-receptor of FGF23 to regulate phosphate homeostasis, secreted Klotho, resulting from the shedding of the KL1-KL2 ectodomain into the b...

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Bibliografiske detaljer
Main Authors: Château, Marie-Thérèse, Araiz, Caroline, Descamps, Simon, Galas, Simon
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2010
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2984606/
https://ncbi.nlm.nih.gov/pubmed/20844315
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