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Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination.

We have inactivated, by gene targeting, the endogenous beta 2-microglobulin gene in a mouse embryonic stem cell line. A cloned fragment of the beta 2-microglobulin gene with the coding sequence disrupted by the insertion of the neomycin-resistance gene was used to transfect the embryonic stem cells....

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Detalles Bibliográficos
Autores principales: Koller, B H, Smithies, O
Formato: Artigo
Lenguaje:Inglês
Publicado: 1989
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC298404/
https://ncbi.nlm.nih.gov/pubmed/2682666
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