Horizontal transfer of penicillin-binding protein genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae.

Resistance to penicillin in clinical isolates of Streptococcus pneumoniae has occurred by the development of altered penicillin-binding proteins (PBPs) that have greatly decreased affinity for the antibiotic. We have investigated the origins of penicillin-resistant strains by comparing the sequences...

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Bibliografiske detaljer

Udgivet i:	Proc Natl Acad Sci U S A
Principais autores:	Dowson, C G, Hutchison, A, Brannigan, J A, George, R C, Hansman, D, Liñares, J, Tomasz, A, Smith, J M, Spratt, B G
Format:	Artigo
Sprog:	Inglês
Udgivet:	National Academy of Sciences 1989
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298386/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2813426/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.22.8842
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