Wild-type p53 can inhibit oncogene-mediated focus formation.
Mutant forms of the p53 cellular tumor antigen elicit neoplastic transformation in vitro. Recent evidence indicated that loss of normal p53 expression is a frequent event in certain types of tumors, raising the possibility that such loss provides transformed cells with a selective growth advantage....
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| Publicado en: | Proc Natl Acad Sci U S A |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
National Academy of Sciences
1989
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298370/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2530586/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.22.8763 |
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