Wild-type p53 can inhibit oncogene-mediated focus formation.

Mutant forms of the p53 cellular tumor antigen elicit neoplastic transformation in vitro. Recent evidence indicated that loss of normal p53 expression is a frequent event in certain types of tumors, raising the possibility that such loss provides transformed cells with a selective growth advantage....

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Bibliographic Details
Main Authors: Eliyahu, D, Michalovitz, D, Eliyahu, S, Pinhasi-Kimhi, O, Oren, M
Format: Artigo
Language:Inglês
Published: 1989
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC298370/
https://ncbi.nlm.nih.gov/pubmed/2530586
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