Homologous recombination in hybridoma cells: heavy chain chimeric antibody produced by gene targeting.
We demonstrate that murine myeloma cells can efficiently mediate homologous recombination. The murine myeloma cell line J558L was shown to appropriately recombine two transfected DNA molecules in approximately 30% of cells that received and integrated intact copies of both molecules. This activity w...
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| 出版年: | Proc Natl Acad Sci U S A |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
National Academy of Sciences
1989
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298311/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2510167/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.21.8507 |
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