Homologous recombination in hybridoma cells: heavy chain chimeric antibody produced by gene targeting.

We demonstrate that murine myeloma cells can efficiently mediate homologous recombination. The murine myeloma cell line J558L was shown to appropriately recombine two transfected DNA molecules in approximately 30% of cells that received and integrated intact copies of both molecules. This activity w...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Autores principales:	Fell, H P, Yarnold, S, Hellström, I, Hellström, K E, Folger, K R
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	National Academy of Sciences 1989
Materias:	Research Article
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC298311/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2510167/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.86.21.8507
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