Homologous recombination in hybridoma cells: heavy chain chimeric antibody produced by gene targeting.

We demonstrate that murine myeloma cells can efficiently mediate homologous recombination. The murine myeloma cell line J558L was shown to appropriately recombine two transfected DNA molecules in approximately 30% of cells that received and integrated intact copies of both molecules. This activity w...

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Bibliografiske detaljer
Main Authors: Fell, H P, Yarnold, S, Hellström, I, Hellström, K E, Folger, K R
Format: Artigo
Sprog:Inglês
Udgivet: 1989
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC298311/
https://ncbi.nlm.nih.gov/pubmed/2510167
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