Germline polymorphisms in genes involved in the IGF1-pathway predict efficacy of cetuximab in wild-type KRAS mCRC patients

PURPOSE: The insulin-like growth factor 1 (IGF1) signalling pathway is an important growth-regulatory pathway, which plays a crucial role in colorectal cancer (CRC) proliferation, differentiation, migration, angiogenesis, and apoptosis. Previous studies showed that hyperactivation of the IGF1-Recept...

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Main Authors: Winder, Thomas, Zhang, Wu, Yang, Dongyun, Ning, Yan, Bohanes, Pierre, Gerger, Armin, Wilson, Peter M., Pohl, Alexandra, Mauro, David J., Langer, Christiane, Rowinsky, Eric K., Lenz, Heinz-Josef
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2982939/
https://ncbi.nlm.nih.gov/pubmed/20935157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-10-2092
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