A let-7 microRNA-binding site polymorphism in KRAS predicts improved outcome in metastatic colorectal cancer (mCRC) patients treated with salvage cetuximab/panitumumab monotherapy

PURPOSE: An inherited mutation in KRAS (LCS6-variant, rs61764370) results in altered control of the KRAS oncogene. We studied this biomarker’s correlation to anti-EGFR monoclonal Antibody therapy (moAbs) response in metastatic colorectal cancer patients (mCRC) patients. EXPERIMENTAL DESIGN: LCS6-var...

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Detalhes bibliográficos
Main Authors: Saridaki, Zenia, Weidhaas, Joanne B., Lenz, Heinz-Josef, Laurent-Puig, Pierre, Jacobs, Bart, De Schutter, Jef, De Roock, Wendy, Salzman, David W., Zhang, Wu, Yang, Dongyun, Pilati, Camilla, Bouché, Olivier, Piessevaux, Hubert, Tejpar, Sabine
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4155520/
https://ncbi.nlm.nih.gov/pubmed/25183481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-14-0348
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