Multiple injections of electroporated autologous T cells expressing a chimeric antigen receptor mediate regression of human disseminated tumor

Redirecting T lymphocyte antigen specificity by gene transfer can provide large numbers of tumor reactive T lymphocytes for adoptive immunotherapy. However, safety concerns associated with viral vector production have limited clinical application of T cells expressing chimeric antigen receptors (CAR...

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Autors principals: Zhao, Yangbing, Moon, Edmund, Carpenito, Carmine, Paulos, Chrystal M., Liu, Xiaojun, Brennan, Andrea L, Chew, Anne, Carroll, Richard G., Scholler, John, Levine, Bruce L., Albelda, Steven M., June, Carl H.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2982929/
https://ncbi.nlm.nih.gov/pubmed/20926399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-2880
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