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BACPTDP: a water-soluble camptothecin pro-drug with enhanced activity in hypoxic/acidic tumors

Hypoxia is a common feature of solid tumors. Up-regulation of hypoxia-inducing factor-1 (HIF-1) occurs in the majority of primary malignant tumors and in two-thirds of metastases, while most normal tissues are negative. HIF-1 induces the glycolytic phenotype, which creates an acidic extracellular mi...

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Detalhes bibliográficos
Main Authors: Adams, David J., Waud, William R., Wani, Mansukh C., Manikumar, Govindarajan, Flowers, James L., Driscoll, Timothy A., Morgan, Lee Roy
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2982901/
https://ncbi.nlm.nih.gov/pubmed/20567829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-010-1388-8
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