A Simple and Computationally Efficient Sampling Approach to Covariate Adjustment for Multifactor Dimensionality Reduction Analysis of Epistasis

Epistasis or gene-gene interaction is a fundamental component of the genetic architecture of complex traits such as disease susceptibility. Multifactor dimensionality reduction (MDR) was developed as a nonparametric and model-free method to detect epistasis when there are no significant marginal gen...

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Detalhes bibliográficos
Main Authors: Gui, Jiang, Andrew, Angeline S., Andrews, Peter, Nelson, Heather M., Kelsey, Karl T., Karagas, Margaret R., Moore, Jason H.
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2010
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2982850/
https://ncbi.nlm.nih.gov/pubmed/20924193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000319175
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